![]() Multicenter, Double-Blind, Parallel-Group Trial Randomized 28 healthy knee replacement surgery patients prospectively to volume-controlled ventilation with 6 or 10 mL/kg predicted body weight (PBW) and found no significant tidal volume-related changes in the selected lung injury biomarkers of these patients (in the two groups) with healthy lungs after 60 minutes of ventilation. "Ventilation with low tidal volumes is associated with a lower risk of development of pulmonary complications in patients without acute respiratory distress syndrome."ĬON: Observed the immediate tidal volume-related changes on lung injury biomarkers in patients with healthy lungs and low risk of pulmonary complications. The study placed patients into tidal volume groups based on the tertiles of tidal volume size during the first 2 days of ventilation. PRO: Conducted a retrospective cohort study to determine the relationship between tidal volume and the onset of pulmonary complications in intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS). Results-Details in Annotated Bibliography Suggests that evidence-based interventions designed to shorten the duration of mechanical ventilation may include low tidal volume ventilation among other strategies, such as paired daily spontaneous awakening and breathing trials, intermittent recruitment maneuvers, and early mobility. Society for Healthcare Epidemiology of America 2014-Strategies To Prevent Ventilator-Associated Pneumonia in Acute Care Hospitals: 2014 Update 1 The Society for Healthcare Epidemiology of America guidelines highlight the use of low tidal volume strategy, and newer publications in the field accept LTVV as an effective intervention. ![]() Low tidal volume (lung-protective) ventilation (LTVV) is associated with decreased acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) progression as well as a shorter length of stay (LOS).
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